@gregory_ms@mastodon.social
Multiple Sclerosis Research powered by GregoryAi
The mineralocorticoid receptor (MR) plays a role in innate and adaptive immune responses. MR is a high-affinity receptor binding both mineraloc Corticoids and glucocortics. MR blockage with SPIRO downregulated inflammation-related spinal cord pathology in mice with EAE model of Multiple Sclerosis.
T helper 17 (Th17) cells are of vital importance in human autoimmune diseases such as multiple sclerosis (MS). Th17 cells produce pro-inflammatory cytokines. Blockade of CD5 reduced production of IL-17A, IFN-γ and GM-CSF by Th17-polarised cells without affecting proliferation. Blockading of CK2 had similar effects but impaired T cell proliferation.
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