Bloom Lab

Bloom Lab

@jbloom_lab@mstdn.science

Lab studying molecular evolution of proteins and viruses. Affiliated with Fred Hutch and HHMI.

Lab website

|http://research.fhcrc.org/bloom/en.html

Google Scholar

|https://scholar.google.com/citations?user=S12x_eQAAAAJ&hl=en

https://twitter.com/jbloom_lab

November 13, 2022

123 Posts 145 Following 1,635 Followers

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Adding to this thread, Yunlong Cao has posted the first experimental data on neutralization escape by BA.2.86: https://twitter.com/yunlong_cao/status/1697318194976010446

Here are data from new XBB.1.5 spike deep mutational scanning by Bernadeta Dadonaite in our group

Go to https://dms-vep.github.io/SARS-CoV-2_XBB.1.5_spike_DMS/htmls/summary_overlaid.html to see how mutations affect:

Neutralization by human XBB breakthrough sera

Spike-mediated pseudovirus entry in 293T-ACE2 cells

Affinity for ACE2

It will be few weeks before we finish pre-print for study, but we wanted to share data now for those interested in SARS2 evolution

Measurements made using lentiviral deep mutational scanning: https://sciencedirect.com/science/article/pii/S0092867423001034

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